12/2/2023 0 Comments William cress sizewiseThe elevation of E2F1 and reduction in Mcl-1 clearly precedes the induction of apoptosis. Treatment of cells with 200 nM flavopiridol results in the rapid elevation of E2F1 and reduction in Mcl-1 levels within 12 hours of treatment. Flavopiridol is associated with a dose-dependent increase in E2F1 protein levels, a corresponding reduction in Mcl-1, and apoptosis in lung carcinoma cells. Given the ability of cyclin/cyclin-dependent kinase 2 antagonists to kill transformed cells, flavopiridol may stabilize E2F1 and enhance apoptosis via repression of Mcl-1. E2F1 leads to transcriptional repression of Mcl-1 and subsequently apoptosis. Flavopiridol treatment leads to apoptosis via a mechanism associated with downregulation of Mcl-1. Provided is a method and vector for modulating apoptosis in a target cell population. 1121 Right Poor Valley, Penningtn Gap, VA 24277ġ6 Kings Crossing Ct, Cockeysville, MD 21030Ģ72 Old Union Church Rd, London, KY 40744ġ878 Tattle Branch Rd, Chilhowie, VA 24319ġ5425 Us Highway 41, Terre Haute, IN 47802ġ76 Decliff Rd N, New Bloomngtn, OH 43341ĥ108 Beckwyck Dr, Fuquay Varina, NC 27526ġ323 Queens Rd Unit 411, Charlotte, NC 28207ġ6400 Bubbling Wells Rd # 50, Dsrt Hot Spgs, CA 92240Ģ216 El Johnson Rd, Little Rock, MS 39337ħ77 N Palm Canyon Dr, Palm Springs, CA 92262ġ0606 Coursey Blvd, Ste A, Baton Rouge, LA 70816Ĭ/O 2 Brattle Square - 3Rd Fl, Cambridge, MA 02138ġ511 East Bay Shore Dr, Palacios, TX 77465ġ430 Commonwealth Dr Ste 102, Wilmington, NC 28403
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